Lifenet Health Readigraft® Blx Dbm Putty versus Autograft in a Posterolateral Fusion Study
نویسنده
چکیده
Materials and Methods: The graft materials were assessed for bone healing efficacy in the athymic rat posterolateral fusion (PLF) model. This model has been extensively characterized to ensure that there are not instances of spontaneous fusion, and instead that the fusion results from the osteogenic, osteoconductive and/or osteoinductive nature of the graft materials. The transverse processes of the L4 and L5 vertebral body were exposed and decorticated. The defect site was then filled with either the test article (BLX Putty) or autograft. Due to the size of the defect and the similarities among the strain of athymic rats, the iliac crest from multiple donor rats were morselized and placed into the defect to represent an autograft control.
منابع مشابه
Lifenet Health Readigraft® Blx Dbm Putty versus Autograft in a Critical Sized Calvarial Defect Study
Materials and Methods: An 8 mm calvarial defect was created in the athymic rat and filled with either the test article (BLX Putty) or autograft. This model is a well-established and validated model for testing the osteoregenerative capacity of bone substitutes wherein an 8 mm defect in the rat calvaria will not spontaneously heal without treatment. The test article was provided in ready-touse a...
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